Acapsil Information Site


Shortens the Inflammatory Wound Healing Phase by 60%

This phase is the most painful to the patient, the most work-heavy for the healthcare professional and its duration correlate strongly with time to wound closure.

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The wound healing process is generally divided into three consecutive and sometimes overlapping phases:

1. Inflammatory Phase, characterised by inflammation, pain, colonisation and possibly infection and necrosis.
2. Proliferative Phase, characterised by a clean wound showing granulation and epithelialisation.
3. Remodelling phase, characterised by maturation and strengthening of the new tissues.

Acapsil - days to clean wound

A wound that does not heal by itself will typically be halted in the Inflammatory Phase. Once a wound is clean, i.e. free of critical colonisation and inflammation, and progresses from the Inflammatory Phase into the Proliferative Phase the pace of the subsequent healing is typically constant (Brown 2012). Therefore, the main aim of supporting wound healing is to assist the wound in getting through the Inflammatory Phase as swiftly as possible.

Furthermore, the Inflammatory Phase is the time when the wound is most work-heavy for the healthcare professional and most painful to the patient with some wounds generating a socially excluding odour.

In a comparative clinical study with 266 patients, Acapsil has shown to reduce the Inflammatory Wound Healing Phase by 60%. The study also showed that this reduction was maintained through the healing process and led to an average 31% reduction in hospital bed-days.


Reduces hospital-bed-days by 31%

A 266 patient comparative clinical study showed that Acapsil patients could be discharged from the hospital one third earlier.

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The comparative clinical study included a wide range of acute and chronic wounds and ulcers with necrosis and severe colonisation or infection. The comparator groups were therefore a topical antibiotic (Gentaxane) and a topical antiseptic containing iodine (Ioddicerin).

Examples of wounds were: Post-surgical wounds, trauma wounds, furuncles and carbuncles.

Examples of ulcers were: Diabetic foot and venous leg ulcers.

The study showed the following reduction in bed days:

  Acapsil vs. Gentaxane Acapsil vs. Ioddicerin
All wounds and ulcers 31%*** 39%***
Only Wounds 41%*** 44%***
Only Ulcers 24%* 42%***


Removes infections - including antibiotic resistant infections

Acapsil strips the bacteria of their main defences. This allows the immune cells to selectively kill the pathogenic bacteria without damaging the healthy and beneficial micro-flora of the wound.

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Pathological bacteria have two key defence systems:
1. They release toxins that inhibit the immune system - thereby preventing wound healing (Monecke et al. 2007; Ho et al. 2012; Bliska et al. 2013).
2. They secrete biofilm and embed themselves in it (Donlan 2001; Flemming & Wingender 2010). Biofilms are non-cellular complex architectural structures consisting of 90-95% water and with well organised own fluid systems. Biofilm prevents immune cells and antibiotics from reaching the bacteria.

Acapsil reaches into all corners and crevices in the wound and due to its strong force of suction it removes the toxins with the wound exudate and sucks water out of the biofilm matrix thereby disrupting the biofilm and exposing the bacteria to the no longer inhibited immune cells.

After in this way disabling the two main bacterial defence systems, the immune system is now able to selectively kill the pathogenic bacteria without harming the beneficial natural micro-flora of the wound. This beneficial micro-flora can now colonise the entire wound surface, complicating it for new harmful bacteria to colonise the wound.

In comparison, antibiotics are indiscriminate in their action – more akin to saturation bombing - and will kill any bacteria sensitive to their effects, whether benign or pathogenic. Once antibiotic treatment stops, the wound is left poorly colonised and therefore open to reinvasion by pathogenic strains.

Another important benefit of Acapsil is that it uses no antibiotic actions, but enables the immune system to kill the bacteria. This avoids any problems in relation to antibiotic resistance and removes the risk of creating new antibiotic resistant strains.

Supports autolytic debridement

Acapsil supports the body’s own immune system thereby effectively facilitating autolytic debridement of the wound.

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Acapsil is not classified as a debrider.

Effective on all types and levels of exudate

Acapsil works well on low to highly exuding wounds with watery to viscous exudate even when containing pus and slough.

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Acapsil is a powder and each grain is a micropore particle comprised of an enormous amount of pores. The micropore particles absorb the exudate and once inside the pores (or capillaries), these effectively pump the wound exudate away from the wound surface towards the surface of the Acapsil layer by capillary forces. To avoid blocking of the pores, these are lined on the inside by a substance that cuts the exudate into smaller pieces. This is the reason why Acapsil can pump away all sorts of exudate including the viscous type.

The pores inside the Acapsil micropore particles transport the exudate away from the wound surface to the outer Acapsil surface. The Acapsil surface is at least 10 times larger than the wound surface, and this supports the evaporation of the exudate to such a degree that Acapsil is efficient at removing exudate even from highly exuding wounds.

Due to its mode of action Acapsil works well on low to highly exuding wounds with watery to viscous exudate even containing pus and slough.

Disrupts biofilm – new and mature

Neither at applications or at dressing changes.

Acapsil is the only wound care product to disrupt both new and mature biofilm

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Bacterial biofilm consist of a gel-like matrix of extracellular material secreted by bacteria. They are inhabited by bacteria that form highly complex, well organised communities. Biofilm consists of up to 95% water and usually has a defined architectural structures, including its own water channel systems, and is optimised for the survival and proliferation of the bacterial communities encased within them.

Biofilm formation is a stepwise transition of bacteria from the planktonic (free swimming) form into its distinct sessile (attached) form with the two forms exhibiting very different gene expression. Within the biofilm the bacteria form aggregates, where they are physically joined together. In wounds, these aggregates or biofilms are typically attached to the wound surface and strongly increase the virulence and survival of the bacteria. Biofilm can be viewed as a defence fortification that is difficult to impossible for the immune cells and antibiotics to penetrate.

When the Acapsil micropore particles are located on top of the biofilm, they will suck the fluid out of the biofilm thereby creating holes in the structure. This disruption exposes the bacteria to the body’s own immune cells allowing them to do their job and clear the infection. This is the case for both new and mature biofilm. Acapsil is the only wound care product to disrupt both new and mature biofilms.

Does not cause pain

Acapsil is safe to use for the healthcare professional as well as for the patient.

Acapsil will not contribute to the creation of antibiotic resistance.

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The components of Acapsil are well known and approved food supplements without known cytotoxicity (toxicity to cells) or risk of allergies.

On the wound

Acapsil has been shown not to cause wound irritation, sensitisation or bleeding.

Acapsil is not absorbed from the wound into the body. It can remain on the wound, where it gradually will fall off as the wound closes.

Acapsil can be rinsed off with water or wiped off with a moist swab. After removal no effect of Acapsil will remain on the wound.

When the wound in clean and hence Acapsil application is discontinued, the dry Acapsil can remain on the wound surface and will fall off in small flakes a healing progresses

Acapsil does not cause pain when applied to the wound.

Acapsil does not cause pain at dressing changes. It the entire wound surface and edges have been covered with Acapsil, the secondary bandage will not stick to the wound surface but be easily removed.


Acapsil removes wound exudate by means of capillary forces. Capillary forces can be very strong, as is the case in Acapsil, but they are only effective as long as excess fluid, i.e. exudate, is present. They stop automatically when excess exudate is no longer present and therefore the wound is not over-dried and the wound bed is not damaged.

No creation of bacterial resistance

Acapsil does not make use of any antiseptic or antibiotic substances.

The use of Acapsil does therefore pose no risk of contributing to the creation of antibiotic resistant bacterial strains.

ISO 14971:2012 Risk Analysis

A risk analysis carried out to the standards of ISO 14971:2012 has found Acapsil to be” Inherently Safe by Design”. This means that the components and the way they are used in Acapsil have not been found to be associated with any known risks.

Extremely easy and quick to use

In difficult to dress areas, Acapsil can be used without a secondary dressing.

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wash_350px dry_350px apply_350px How to dress the wound.

These 4 simple steps is all there is to it.

The wound needs to be cleaned as thoroughly as possible preferably using water. Then it is dabbed dry with a swab, Acapsil is applied covering the entire wound surface and the wound edges. A 4 ply swab or a different highly permeable secondary dressing is applied to keep the Acapsil in place.

If the wound is in a difficult to dress area, the secondary dressing can be omitted. This may sometimes require an extra application of Acapsil before the wound is clean - but not necessarily.

As opposed to TNP (topical negative pressure wound therapy) or thick occlusive dressings, the secondary dressing is very discrete, non-bulky and easy to conceal under clothes which is a social advantage.

Please see the How to Use section of this website.

Effective on all types of wounds and ulcers

Acapsil has shown strong beneficial effects on all types of acute and chronic wounds and ulcers, independently of aetiology.

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In a 266 patient comparative clinical study Acapsil was trialled on a wide range of wounds and ulcers that were severe enough to require intervention by a doctor. The wounds and ulcers would be critically colonised or infected and could contain necrosis.

Examples of wounds and ulcers included in the trial:
- diabetic foot ulcers,
- venous leg ulcers,
- post-surgical wounds / dehisced wounds
- trauma
- phlegmons
- carbuncles and furuncles
- burns of degree III-IV

Acapsil is intended for use during the Inflammatory Wound Healing Phase and for all wound and ulcer types, Acapsil shortened the Inflammatory Phase by 60%.

A common characteristic of these wounds is that the wound has entered a vicious cycle where the exudate has become almost toxic and inhibiting. Removing the exudate properly, enables the wound to break free of this cycle and resume healing.

The acceleration of reaching a clean wound is maintained throughout the following wound healing phases and resulted in an overall 31% reduction in hospital bed-days. The reduction in bed-days was 41% for wounds, which typically are not caused by any underlying disease process, and a surprising 24% for ulcers, which are caused by an underlying disease process and where the healing process consequently is inhibited.

On a case-study basis, Acapsil has been trialled on several chronic wounds and ulcers between 2 and 20 years of age. In all cases Acapsil resulted in the closure of these wounds and ulcers.